克罗米酚对男性较高促性腺素性功能减退症有效

纽约（消息来源卫生版）1月四日报道：据发表在12月出版发行的《生育与不育》周刊的一项份文件指出克罗米萘对部分高促性腺素性功能减退的男同性恋症状不利于。来自伯明翰阿拉巴马国立大学的该份文件的第一作者Scott J. Whitten耶鲁大学在不感兴趣路透通讯社采访时却说：“病变或获得性HH症状在不感兴趣侵害性更多和更为高昂的放射治疗（例如注射促性腺激素类）前来进行4个月的克罗米萘早先放射治疗是不利于的。”Whitten耶鲁大学和威尔森分析了克罗米萘对10名HH男同性恋症状（HH是所致男同性恋不育的少见因素）有否直接。份文件指为克罗米萘放射治疗1年后，4名卡尔曼(其族)综合征症状中只有一名症状的乳腺剂量增加而全小脑功能减退症症状的乳腺忽视症状均很难得到提升。相反，该份文件指出3名成年人中风的病变HH男同性恋症状经过3个月克罗米萘的放射治疗乳腺剂量有了明显增加。目前为止该组症状已有两名以后了身体卫生。Whitten耶鲁大学却说：“除非对克罗米萘放射治疗很难中间体，我们不会因为抗抑郁药停止对症状适用该抑制剂。”最后作者总结却说：“因为条件更少，对HH症状促性腺激素类抑制剂和克罗米萘的随机分析难以来进行，然而利用多系列的严格同样标准对症状来进行分级也许希望再进一步可验证克罗米萘以后男同性恋高身体卫生的直接性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

校对：蓝色宿命

校对： 张靖